By Robert S.; Thimann, Kenneth V.; Marrian, G. F. Harris
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Extra info for Advances in Research and Applications
Grande and Jiminez (1942) and Peraita (1942) termed the condition ‘(cochlear neuritis” when it appeared in patients with retrobulbar neuropathy and signs of cord damage during the Spanish Civil War. In the patients in Changi Camp the deafness was rarely complete and in many appeared to be confined to sounds of certain pitch only, although the range would vary from patient to patient. The defect might be regarded as an “auditory scotoma” analogous to that of retrobulbar neuropathy. Sometimes it was the only sign of deficiency, but more often accompanied defective vision and epithelial lesions.
Stomatitis and scrota1 dermatitis precede or accompany a high percentage of cases. Defective vision also frequently occurs. This may be due to one of two lesions. Firstly, a punctate granular change of the cornea. This disorder is now a well recognized feature of B complex deficiency and Metivier (1941) who called the condition corneal epithelial dystrophy” noted its association with burning sensations in the feet of patients in Trinidad. He found rapid improvement on treatment DIETARY NEUROPATEIIES 23 with riboflavin and therefore regarded the lesion as due to riboflavin deficiency.
He had no proof to offer for his suggestion. Shattuck in 1928 had suggested that alcoholic peripheral neuritis might properly be regarded as beriberi since it was caused by a failure to take or assimilate food containing a sufficient quantity of vitamin B. Strauss in 1933 showed that alcoholic peripheral neuritis improved rapidly when treated with vitamin B concentrates and liver extracts parenterally, although large quantities of alcohol were still consumed, and his findings were confirmed by Jolliffe, et al.
Advances in Research and Applications by Robert S.; Thimann, Kenneth V.; Marrian, G. F. Harris