Alzheimer's Disease - download pdf or read online

By Hooper N.M. (ed.)

ISBN-10: 1617371610

ISBN-13: 9781617371615

This article brings jointly the most recommendations of biochemistry, cellphone biology, and molecular biology which are getting used to enquire the molecular foundation of Alzheimer's illness. It presents a precis of at the moment on hand healing brokers and clients for destiny medicines.

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Extra info for Alzheimer's Disease

Sample text

Even though the current generation of medications, the cholinesterase inhibitors (CEIs), has produced only modest benefits, our concept of an “effective” therapy has matured considerably over this time. A less visible but equally important advance has been a quantum leap in expertise in clinical trial methodology. This chapter reviews the methodological underpinnings of clinical trials in AD: patient selection issues, key design issues, and an overview of currently available agents and the prospects for drugs of the future.

Garner, C. , Saunders, A. , et al. (1994) Isoform-specific interactions of Apolipoprotein-E with the microtubule-associated protein MAP2c — implications for Alzheimer’s-disease. Neurosci. Lett. 182(1), 55–58. 35. Nathan, B. , Sanan, D. , Weisgraber, K. , Mahley, R. , and Pitas, R. E. (1994) Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 264, 850–852. 36. , Laakso, M. , et al. (1996) SPECT and MRI analysis in Alzheimer’s disease: relation to apolipoprotein E epsilon-4 allele.

Neurochem. 69, 2432–2440. 71. , Xia, M. , Tanzi, R. , and Hyman, B. T. (1997) Developmental regulation of presenilin mRNA expression parallels notch expression. J. Neuropath. Exp. Neurol. 56, 40–44. 72. Kim, T. , Pettingell, W. , Jung, Y. , Kovacs, D. , and Tanzi, R. E. (1997) Alternative cleavage of Alzheimer’s associated presenilins during apoptosis by caspase-3 family proteases. Science 277, 373–376. 73. , et al. (1998) Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling.

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Alzheimer's Disease by Hooper N.M. (ed.)

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