By Chandan K. Sen, Lester Packer, Patrick A. Baeuerle
This quantity addresses oxidant-reduction or redox and antioxidant delicate molecular mechanisms and the way they're implicated in numerous illness methods. attainable recommendations to pharmacologically and/or nutritionally control such redox-sensitive molecular responses are emphasised. Key Features:* Reactive species as intracellular messengers* Redox law of mobile responses* scientific implications of redox signaling and antioxidant treatment
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Additional resources for Antioxidant and Redox Regulation of Genes
A. 90, 70547058. Mtiller, J. , Cahill, M. , Rupec, R. , Baeuerle, P. , and Nordheim, A. (1997). Antioxidants as well as oxidants activate c-los via Ras-dependent activation of extracellularsignal-regulated kinase 2 and Elk-1. Eur. J. Biochem. 244, 45-52. , and Schepers, G. (1997). Evidence for peroxynitrite as an oxidative stress-inducing compound of aqueous cigarette smoke fractions. Carcinogenesis 18, 295-301. , and Aubry, J. -M. (1996). Water-soluble naphthalene derivatives as singlet oxygen (102, ~Ag)carriers for biological media.
Redox Regulation of Gene Expression 23 electrophoresis is still a useful technique. , 1985; Keyse and Tyrrell, 1989). Despite these important findings, these protein-based approaches have, for the most part, been supplanted by more powerful and sensitive nucleic acid-based techniques. Nucleic-acid based techniques are primarily based on analysis at the level of cellular mRNA. Chronologically, they include differential hybridization and subtractive hybridization, followed by differential display, and then restriction fragment differential display, serial analysis of gene expression (SAGE), and gene chips.
Foote, C. , and Clennan, E. L. (1995). Properties and reactions of singlet oxygen. In "Active Oxygen in Chemistry" (C. S. Foote, J. S. Valentine, A. Greenberg, and J. F. ), pp. 105-141. Blackie Academic and Professional, London. , Abels, C, Goetz, A. , and Sies, H. (1997). Porphyrins preferentially accumulate in a melanoma following intravenous injection of 5-aminolevulinic acid. Biol. Chem. 378, 51-57. , and Shimizu, N. (1995). Hydrogen peroxide preferentially enhances the tyrosine phosphorylation of epidermal growth factor receptor.
Antioxidant and Redox Regulation of Genes by Chandan K. Sen, Lester Packer, Patrick A. Baeuerle